Mobocertinib 40 mg is a prescription medication used to treat adult patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) with EGFR exon 20 insertion mutations. It is a first-in-class drug, which means it is the first to be approved for this indication.
How does it work?
Mobocertinib works by blocking the activity of the epidermal growth factor receptor (EGFR), a protein that helps cancer cells grow and spread. EGFR exon 20 insertion mutations are a type of genetic mutation that occurs in the EGFR gene. These mutations make the EGFR protein more active, which can lead to the growth of cancer cells. for more information visit
What is the dosage?
The recommended dose of mobocertinib is 40 mg once daily. It is taken as an oral capsule.
What are the side effects?
The most common side effects of mobocertinib are diarrhea, rash, nausea, stomatitis (inflammation of the mouth), vomiting, decreased appetite, paronychia (inflammation of the nail folds), fatigue, dry skin, and musculoskeletal pain.
Serious side effects that can occur with mobocertinib include QTc prolongation (a heart rhythm disorder), interstitial lung disease/pneumonitis (inflammation of the lungs), and cardiac toxicity (heart problems).
Is it safe to take mobocertinib?
Mobocertinib can cause serious side effects, so it is essential to talk to your doctor about the risks and benefits of this medication before taking it. Mobocertinib should not be used by women who are pregnant or breastfeeding. It should also be avoided by people with certain heart conditions or liver problems.
What are the FAQs about mobocertinib?
Here are some frequently asked questions about mobocertinib:
- What is the difference between mobocertinib and other EGFR inhibitors?
Mobocertinib is a first-in-class drug, which means it is the first to be approved for treating NSCLC with EGFR exon 20 insertion mutations. Other EGFR inhibitors, such as gefitinib and osimertinib, are not as effective in treating this type of cancer.
- How long does it take for mobocertinib to work?
The effects of mobocertinib can vary from person to person. Some people may start to see a response to treatment within a few weeks, while others may take longer.
- Is there anything I can do to reduce the side effects of mobocertinib?
There are a few things you can do to reduce the side effects of mobocertinib. These include:
* Taking the medication with food.
* Drinking plenty of fluids.
* Using a mild soap and avoiding harsh skin cleansers.
* Managing your stress levels.
If you experience any side effects that are bothersome or severe, talk to your doctor.
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