Panovir (sofosbuvir-velpatasvir) is used to treat HCV infection caused by all genotypes. Panovir is widely popular for treating HCV infection.
Description: It is a fixed-dose combination tablet containing sofosbuvir and velpatasvir for oral administration. Sofosbuvir is a nucleotide analog HCV NS5B polymerase inhibitor and velpatasvir is an NS5A inhibitor.
Panovir (sofosbuvir-velpatasvir) combination is indicated for the treatment of adult patients with chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5, or 6 infections
– without cirrhosis or with compensated cirrhosis
– with decompensated cirrhosis for use in combination with ribavirin
Dosage & Administration
The recommended dosage is one tablet (400 mg of Sofosbuvir and 100 mg of Velpatasvir) taken orally once daily. Recommended treatment regimen:
– Patients without cirrhosis and patients with compensated cirrhosis (Child-Pugh A) – one tablet once daily for 12 weeks
– Patients with decompensated cirrhosis (Child-Pugh B or C) – one tablet once daily and Ribavirin for 12 weeks. The recommended dosage of Ribavirin is based on body weight (1000 mg/day for patients < 75 kg and 1200 mg/day for ≥ 75 kg, in two divided doses/day)
No dosage recommendation can be given for patients with severe renal impairment (eGFR ≤ 30 mL/min/1.73 m2) or ESRD, due to higher exposure to the predominant sofosbuvir metabolite.
Side Effects: The most common side effects of the Panovir (sofosbuvir-velpatasvir) combination include headache and tiredness. Treatment may slow the heart rate and other symptoms when taken with amiodarone (a medicine used to treat certain heart problems).
Precautions: Serious symptomatic bradycardia may occur in patients taking amiodarone, particularly in patients also receiving beta-blockers or those with underlying cardiac comorbidities and/or advanced liver disease. Coadministration of amiodarone with the Sofosbuvir and Velpatasvir combination is not recommended. In patients without alternative viable treatment options, cardiac monitoring is recommended.
Use in Pregnancy & Lactation: No adequate human data are available to establish whether or not Sofosbuvir and Velpatasvir combination pose a risk to pregnancy outcomes. If Sofosbuvir and Velpatasvir combination is administered with Ribavirin, the combination regimen is contraindicated in pregnant women and in men whose female partner is pregnant or going to be pregnant in the next six months.
Drug Interaction: Drugs may decrease the concentrations of sofosbuvir and/or velpatasvir: Antacids, H2-receptor antagonists, Proton-pump inhibitors, etc.
Coadministration is not recommended with topotecan, Carbamazepine, Phenytoin, Phenobarbital, Oxcarbazepine, Rifabutin, Rifampin, Rifapentine, efavirenz, Tipranavir, Ritonavir, Hypericum perforatum.
Coadministration of Sofosbuvir and Velpatasvir combination, with Rosuvastatin, Atorvastatin may significantly increase the concentration of Rosuvastatin, Atorvastatin.
Overdose: If an overdose occurs the patient must be monitored for evidence of toxicity. Treatment of overdose includes monitoring of vital signs as well as observation of the clinical status of the patient.
Storage: Store in a cool and dry place (preferably below 30°C). Keep out of reach of children
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