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Lorlatinib 100 mg (Lorbrexen)

Generic Name: Lorlatinib

Manufacturer: Everest Pharma

Tablet: 30’s Pot

Originator: Lorbrena by Pfizer Inc.

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Lorlatinib 100 mg (Lorbrexen) is a highly effective targeted therapy for patients with ALK-positive non-small cell lung cancer. Learn more about this medication, including its benefits, side effects, and dosage.


Introduction: Non-small cell lung cancer (NSCLC) is the most common type, accounting for 85% of all cases. Among patients with NSCLC, those diagnosed with ALK-positive tumors have a specific mutation in the anaplastic lymphoma kinase (ALK) gene. This mutation can be targeted with a medication called Lorlatinib, designed to inhibit cancer cell growth and spread. In this article, we will explore the benefits, side effects, and dosage of Lorlatinib 100 mg, effective treatment for ALK-positive NSCLC.

Benefits of Lorlatinib 100 mg (Lorbrexen):

  • Highly effective in treating ALK-positive NSCLC
  • Can help shrink tumors and slow disease progression
  • May provide a longer period of disease control than other treatments
  • Can be taken orally at home

Side Effects of Lorlatinib 100 mg (Lorbrexen):

  • Nausea, vomiting, and diarrhea
  • Fatigue and weakness
  • Elevated liver enzymes
  • Difficulty breathing and coughing
  • Weight gain and edema

Dosage and Administration of Lorlatinib 100 mg:

  • Typically taken once daily with or without food
  • The dose may be adjusted based on individual response and tolerance
  • Swallow tablets whole, do not crush or chew
  • Store at room temperature away from moisture and heat


FAQ about this medicine

Q: What is ALK-positive NSCLC?
A: ALK-positive NSCLC is a type of lung cancer characterized by a specific mutation in the ALK gene.
Q: How is Lorlatinib 100 mg different from other treatments?
A: Lorlatinib 100 mg is a targeted therapy that specifically inhibits the growth and spread of cancer cells in patients with ALK-positive NSCLC. It is often more effective and better tolerated than traditional chemotherapy.
Q: Who is a candidate for Lorlatinib 100 mg?
A: Patients with ALK-positive NSCLC who have progressed on other therapies are typical candidates for Lorlatinib 100 mg.
Q: How long does Lorlatinib 100 mg take to work?
A: The time it takes for Lorlatinib 100 mg to work can vary depending on the individual, but it may take several weeks or months to see a response.
Q: How is Lorlatinib taken?
A: Lorlatinib is taken orally, usually once a day with or without food. The medication is available in capsule form and should be swallowed whole.
Q: How effective is Lorlatinib?
A: Lorlatinib is effective in treating non-small cell lung cancer in patients who have specific genetic mutations, including those with ALK and ROS1 mutations. Clinical trials have shown that it can help shrink tumors.
A: Are there any medications or substances that should be avoided while taking Lorlatinib?
A: Yes, it's important to inform your doctor of all medications, vitamins, and herbal supplements you're taking before starting Lorlatinib. Some medications and substances may interact with Lorlatinib, potentially causing unwanted side effects or reducing its effectiveness. It's especially important to avoid grapefruit or grapefruit juice, as they can increase the amount of Lorlatinib in your body, which can be harmful.
Q: Can Lorlatinib cure cancer?
A: While Lorlatinib can help slow or stop the growth of cancer cells, it is not a cure for cancer. It is considered a targeted therapy, which can help manage the disease by targeting specific proteins that promote cancer growth. In some cases, Lorlatinib may be used in combination with other treatments, such as chemotherapy or radiation, to help improve overall cancer management.
Q: How long does Lorlatinib stay in the body?
A: Lorlatinib has a half-life of approximately 24-30 hours, which means that it takes about that amount of time for half of the medication to be eliminated from the body. However, the medication may continue to have effects on the body for several days after the last dose, depending on the individual's metabolism and other factors.
Q: Can Lorlatinib be used to treat other types of cancer?
A: Currently, Lorlatinib is primarily used to treat non-small cell lung cancer in patients with ALK or ROS1 mutations. However, researchers are exploring its potential use in other types of cancer, including pediatric solid tumors and brain metastases. It is important to discuss treatment options with a healthcare provider to determine the most appropriate treatment plan for an individual's specific cancer type and stage.


In conclusion, Lorlatinib is a medication used to treat non-small cell lung cancer in patients with specific genetic mutations, including ALK and ROS1 mutations. It works by blocking the action of specific proteins that promote cancer growth. While Lorlatinib can be effective in shrinking tumors and slowing the progression of the disease, it is not a cure for cancer. Common side effects of Lorlatinib include fatigue, cough, nausea, and diarrhea, among others. As with any medication,

it’s important to discuss the potential benefits and risks of Lorlatinib with a doctor to determine if it’s an appropriate treatment option for an individual’s specific condition.


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